功能连接梯度揭示了功能神经障碍中改变的等级皮质组织
medRxiv : the preprint server for health sciences
|June 12, 2025
概括
功能神经障碍 (FND) 显示出异常的大脑组织,在传感运动,感觉和表达系统中观察到改变的连接梯度. 这些发现突出了基于梯度的神经成像,以了解FND的大脑变化.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经学 神经学
背景情况:
- 功能神经障碍 (FND) 在精神病学和神经学的交叉点提出了挑战.
- 传统的神经成像方法可能会掩盖大脑复杂的功能网络架构.
- 基于梯度的方法为宏观皮质组织提供了新的视角.
研究的目的:
- 通过基于梯度的方法来研究FND中的宏观皮质组织.
- 为了比较FND患者,健康对照组和精神病控制组之间的功能连接梯度.
- 探索改变的梯度和FND症状严重程度之间的关联.
主要方法:
- 分析了64名FND患者的休息状态fMRI数据,61名健康对照组 (HCs) 和62名精神病控制组 (PCs).
- 计算了功能连接梯度以绘制皮质组织图.
- 进行了群组比较和相关性分析,控制了相关的共变量.
主要成果:
- 与HC和PC相比,FND患者在所有三个主要功能连接梯度中都表现出显著的变化.
- 具体的梯度变化包括感觉运动区域的变化,感觉系统差异化的改变,以及前带皮层功能分离的减少.
- 几个变化的区域与FND和体质症状严重程度相关.
结论:
- 这项研究提供了非典型的等级性大脑组织在FND的新证据.
- 基于梯度的神经成像是一种有价值的工具,用于识别FND的机械相关变化.
- 这些发现有助于我们更好地了解FND的神经基础.
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