异常性热囊细胞中的缺氧与母亲的肥胖和后代的神经行为有关
Fatima Gunter-Rahman1,2,3, Shayna Mallett2,3, Frédérique White4
1Harvard-MIT Program in Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA.
iScience
|June 12, 2025
概括
孕产妇肥胖 (MO) 可能导致儿童的神经行为障碍 (NBI). 这项研究发现,外性热囊细胞 (EVT) 中的胎盘缺氧是将母亲肥胖与后代NBI联系起来的关键机制.
科学领域:
- 生殖生物学 生殖生物学
- 发育神经科学的发展神经科学.
- 基因组学就是基因组学.
背景情况:
- 孕产妇肥胖 (MO) 与后代的神经行为障碍 (NBI) 有关.
- 胎盘在胎儿编程中的作用和MO相关的NBI背后的机制尚未完全理解.
研究的目的:
- 为了研究胎盘机制,在母亲的肥胖和后代的神经行为障碍之间的关联.
主要方法:
- 单核RNA测序人类胎盘从母亲与MO和瘦控制.
- 对母亲和胎儿面向的胎盘侧面基因表达的分析.
- 与来自Gen3G队列的后代NBI数据的相关性分析.
- 在体外实验中,暴露外性热囊细胞 (EVTs) 于缺氧.
主要成果:
- MO胎盘在多种细胞类型中表现出高调的低氧反应基因.
- 母亲面对低氧基因表达与后代NBI相关.
- EVT显示了NBI相关基因的最高表达,这与缺氧特征有关.
- 培养EVT中的缺氧增加了NBI基因表达,调解了母亲BMI和EVT NBI基因表达之间的44%的关联.
结论:
- 异位囊细胞 (EVT) 中的缺氧是对胎儿暴露于母亲肥胖的神经发育编程的一个关键因素.
- 这种胎盘缺氧可能是驱动肥胖母亲后代神经行为障碍的关键机制.
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