基因组学揭示黄金葡萄球菌在长期尿道导管治疗期间仍然存在,尽管进行了抗菌疗法和导管交换
Research square
|June 12, 2025
概括
耐多药性黄金葡萄球菌 (Staphylococcus aureus) 在长期使用尿导管者中经常以无症状的细菌尿症持续存在. 标准治疗方法经常无法消除这种持久性尿病原体,这突显出一个重大的临床挑战.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
背景情况:
- 尿导管是与尿路感染相关的常见医疗器械.
- 长期使用尿道导管 (LTUC) 的人面临着与导管相关的尿路感染 (CAUTI) 和无症状细菌尿 (ASB) 的高风险.
- 许多引起ASB和CAUTI的泌尿病原体仍未得到充分研究.
研究的目的:
- 通过使用全基因组测序,在患有LTUC的个体中研究未经研究的尿病原体 * Staphylococcus aureus*.
- 了解导致LTUC患者ASB和CAUTI的*S. aureus*的持久性和基因组特征.
主要方法:
- 来自20名LTUC患者的153个纵向*S. aureus*分离物的全基因组测序.
- 对隔离物相关性,抗菌素耐药性和病毒性基因携带的分析.
- 基因组数据与临床结果和治疗暴露的相关性.
主要成果:
- 大多数*S. aureus*菌株是多药耐药 (MDR),包括耐甲林*S. aureus* (MRSA),属于序列类型5.
- 同样的*S. aureus*菌株作为ASB持续平均13周,通常不受抗生素治疗或导管更换的影响.
- 纵向菌株显示出高度的遗传相关性,稳定的耐药性和毒性特征,其中一种菌株转变为症状性CAUTI.
结论:
- 耐多药性黄金菌可以在LTUC患者中建立长期无症状的细菌性尿症.
- 在LTUCs中减少微生物的标准策略在根除持久性*S. aureus*方面基本上无效.
- MDR *S. aureus*的基因组稳定性有助于其持久性和可能引起CAUTI的可能性.
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