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Updated: Jun 13, 2025

CRISPR-Mediated Reorganization of Chromatin Loop Structure
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CRISPR-Mediated Reorganization of Chromatin Loop Structure

Published on: September 14, 2018

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破坏YY1介导的超强增强剂-促进剂循环驱动在哺乳动物干细胞衰老期间的转录组变化

Weiwei Dang, Luyang Sun, Brenna McCauley

    Research square
    |June 12, 2025
    PubMed
    概括

    干细胞衰老导致功能衰退. 转录因子YY1通过维持超强增强剂 (SE) 促进子循环来稳定基因表达,防止人类介质干细胞 (MSC) 中与年龄相关的变化.

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    Oct4GiP Reporter Assay to Study Genes that Regulate Mouse Embryonic Stem Cell Maintenance and Self-renewal08:01

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