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Updated: Jun 14, 2025

Assessment of Spontaneous Alternation, Novel Object Recognition and Limb Clasping in Transgenic Mouse Models of Amyloid-β and Tau Neuropathology
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打击阿尔茨海默病的多种病因,以挽救行为缺陷

Madhu Ramesh1, Chenikkayala Balachandra1, Ashish Kumar1

  • 1Bioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research Bengaluru Karnataka 560064 India tgraju@jncasr.ac.in.

Chemical science
|June 12, 2025
PubMed
概括

一种新的混合药物设计方法针对多种阿尔茨海默病 (AD) 病理. 化合物DM4有效地减少了AD小鼠模型中的粉样蛋白负担,神经炎症和认知衰退,显示了神经退行性疾病治疗的前景.

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