相关实验视频

Updated: May 5, 2026

Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish Embryos

Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish Embryos

Published on: September 9, 2015

从呈现到预后:由于Citrobacter Freundii引起的多焦点脑微的挑战性病例

Varsha Nandwana¹, Liam M Cleary¹, Thomas V Kodankandath¹

¹Department of Internal Medicine, Section of Neurology, Carilion Clinic-Virginia Tech Carilion School of Medicine, Roanoke, USA.

European journal of case reports in internal medicine

|June 12, 2025

概括

中枢神经系统 (CNS) 感染的Citrobacter freundii在成年人中很罕见,但非常致命. 这一案例凸显了诊断方面的挑战,以及对高风险患者的早期识别和量身定制治疗的需要.

科学领域:

神经学神经学
传染性疾病传染性疾病
微生物学微生物学

背景情况:

常见的Citrobacter freundii是一种不常见的中枢神经系统 (CNS) 感染的原因,主要发生在新生儿身上.
在成年人中,中枢神经系统感染C. freundii很少见,并与显著的死亡率相关.
患有并发症的患者有更高的严重后果风险.

研究的目的:

报告一个罕见的致死性败血性脑病变的病例,由Citrobacter freundii引起,在一个患有多种并发病症的成年人身上.
讨论C. freundii中枢神经系统感染的诊断挑战和管理策略.
强调早期识别和适当的抗微生物治疗的重要性.

主要方法:

一个有异常神经表现的成年男性的病例报告.
诊断工作包括神经成像,脑脊液 (CSF) 分析和血液/伤口培养.
治疗涉及基于已识别的病原体和耐药机制的向抗生素治疗.

主要成果:

患者出现了胃肠道症状,迅速进展到改变精神状态和发作.
神经成像显示了内静脉气体和脑神经变化.
在血液和伤口培养中发现了C. freundii;CSF的发现是非特异性的.
尽管采取了适当的抗生素,但患者的临床状况恶化并死亡,尸检证实有脑微.

结论:

Citrobacter freundii可以引起严重的败血性脑病变,并具有非典型的神经症状.
诊断困难源于非特定的CSF发现和不寻常的呈现.
有效的管理需要考虑C. freundii的耐药性机制,如AmpCβ-乳糖酶的产生,以及及时的,量身定制的抗菌疗法.
早期检测和干预对于改善高风险个体的结果至关重要.

关键词:

在Citrobacter freundii中使用.脑部,脑部.中枢神经系统感染中枢神经系统感染

更多相关视频

Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes

Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes

Published on: April 19, 2024

Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis

Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis

Published on: September 20, 2024

相关概念视频

Acute Pyelonephritis II: Diagnostic Studies and Management

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...

Bacterial Meningitis I: Introduction

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...

Brain Abscess l: Introduction

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial...