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Updated: Jun 14, 2025

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
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通过Piperazate合成酶的基质性,获得含有-键的异循环

Yongxin Li1, Angelina Osipyan1, Niels A W de Kok1

  • 1Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, Groningen 9713 AV, The Netherlands.

ACS catalysis
|June 12, 2025
PubMed
概括

这项研究展示了酶,酸盐合成酶 (PZS) 和N-基化单氧化酶 (NMO) 如何被设计为新型N-N键形成. 这些生物催化剂产生多样化的-异循环,扩大药物发现的可能性.

关键词:
其他N-异环环.在N-基化单氧基酶.生物催化剂的生物催化剂氨酸是二胺的组成部分.形成-键的酶.皮佩拉酸盐合成酶的作用

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