主要单边全膝关节关节整形术后的阿片类药物使用因年龄而异
Shah Fahad1, Jason A Bryman1, Michael A Behun1
1Colorado Joint Replacement, Denver, CO, USA.
Arthroplasty today
|June 12, 2025
概括
年轻的患者在膝关节置换手术后使用了更多的阿片类药物,但这可能是由于其他因素,如先前的阿片类药物使用. 仅仅年龄并不能预测手术后的阿片类药物消费量更高.
科学领域:
- 整形外科手术 整形外科手术
- 疼痛管理 疼痛管理
- 药理学 药理学是指药理学的学科.
背景情况:
- 在关节整形术后未使用的处方阿片类药物构成了重大挑战.
- 患者年龄对术后阿片类药物消费的影响尚不清楚.
- 形成了一个假设,称老年患者在全膝关节整形术 (TKA) 后消耗的阿片类药物比年轻患者少.
研究的目的:
- 为了研究患者年龄和阿片类药物使用在初级单边全膝关节整形术 (TKA) 后的关系.
- 确定年龄是否是术后阿片类药物消费的独立预测因素.
- 确定影响不同年龄组阿片类药物使用的潜在混因素.
主要方法:
- 对506名初级单边TKA患者的回顾性审查.
- 将患者分成各个年龄组的分层 (40-49,50-59,60-69,70-79,80+).
- 以吗啡毫克相当量 (MME) 计算外科手术期间的阿片类药物使用量,并识别持续性阿片类药物使用者 (POU).
主要成果:
- 年轻的患者更有可能成为慢性手术前阿片类药物使用者,并同时使用抗抑郁药,THC和尼古丁等药物.
- 持久性阿片类药物使用者 (POU) 的百分比在年轻年龄组中最高,并且随着年龄的增长而下降.
- 较年轻的患者在术后三个月内使用阿片类药物的持续时间增加,门诊性MME总数增加.
结论:
- 较年轻的患者在TKA后显示出更高的术后阿片类药物使用率,可能受术前阿片类药物使用和其他物质使用的影响.
- 年龄可能不是增加阿片类药物消费的独立预测因素.
- 识别和管理可修改的风险因素对于优化TKA后疼痛控制至关重要.
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