使用标准三重疗法和顺序疗法的除率的比较Helicobacter pylori
Yuri Kim1, Ji Yong Ahn1, Hwoon-Yong Jung1
1Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Asan Digestive Disease Research Institute, Seoul, Korea.
概括
序列疗法 (SQ) 在 Helicobacter pylori 根除方面显示出更高的第一线疗效,而不是标准的三重疗法 (STT). 尽管不良事件增加,但SQ可能会替代STT在以前未接受治疗的患者中.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 针对 Helicobacter pylori 根除 (HPE) 的标准三重疗法 (STT) 面临着由于抗生素耐药性的治疗失败的日益增加.
- 序列疗法 (SQ) 是一种替代方法来对抗抗性并改善HPE结果.
研究的目的:
- 为了比较7天STT与10天SQ对HPE的疗效,合规性和安全性.
- 在现实临床环境中评估这些疗法的有效性.
主要方法:
- 一项时间分类的队列研究分析了接受HPE治疗的789名患者.
- 患者接受了7天STT (n=378) 或10天SQ (n=411).
- 根除率,遵守和不良事件在各组之间进行了比较.
主要成果:
- 作为一线治疗,SQ实现了显著更高的根除率 (84.7%),而不是7天STT (74.1%),作为一线治疗 (p<0.001).
- 不良事件在SQ (17.5%) 与STT (11.1%) (p=0.01) 之间更频繁,但遵守程度相似 (98.1%与96.8%).
- 在STT和SQ之间,整体根除率没有显著差异 (98.3%和97.4%).
结论:
- 序列疗法 (SQ) 对于最初的Helicobacter pylori根除,比7天的标准三重疗法 (STT) 更有效.
- 在以前未接受过治疗的患者中,SQ是潜在的STT替代品.
- 进一步的研究可能会探索优化SQ疗法以减轻不良事件.
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