相关实验视频

Updated: Jun 13, 2025

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

PD-1 调节糖解路径以逆转异常的CD4+T细胞分化并缓解哈西莫托甲状腺炎

Xiao Jiang¹, Tao Luo¹, Xinyu Zhao¹

¹Endocrinology and Metabolism Department, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.

|June 12, 2025

概括

这项研究表明,编程细胞死亡蛋白1 (PD-1) 影响CD4+T细胞中的葡萄糖代谢,为治疗哈西莫托提供了潜在的点.

科学领域:

免疫学免疫学免疫学
内分泌学在内分泌学.
代谢研究研究代谢研究

背景情况:

哈西莫托甲状腺炎 (HT) 是一种常见的自身免疫性疾病,没有确定的治疗方法.
CD4+ T 细胞子集的失调,特别是 T 调控细胞 (Tregs) 和 T 辅助 17 (Th17) 细胞,与HT 病原发生有关.
变化的细胞代谢,特别是糖解,在自身免疫性疾病中越来越多地被识别出来.

研究的目的:

调查编程细胞死亡蛋白1 (PD-1) 在调节CD4+T细胞分化过程中的糖解中的作用,在哈西莫托甲状腺炎的背景下.
阐明PD-1调制对HT中Treg/Th17细胞和糖解路径平衡的影响.

主要方法:

乳酸盐和葡萄糖水平的评估使用测试套件.
对HK2和LDHA蛋白表达的西部斑点分析.
流细胞计分析Glut1表达和Treg/Th17细胞比率.

主要成果:

与健康对照人群相比,哈西莫托甲状腺炎患者的葡萄糖溶解水平升高.
在HT患者中,CD4+ CD25+ Tregs的比例降低,CD4+ TH17细胞的比例增加.
抑制PD-1导致糖解和CD4+T细胞分化的改善.

结论:

PD-1在调节异常CD4+T细胞分化的过程中起着至关重要的作用.
通过PD-1抑制向糖解路径为HT提供了潜在的治疗策略.

关键词:

CD4+ T 细胞是 CD4+ T 细胞.哈西莫托的甲状腺炎在PD‐1中,Th17/Treg 的不平衡.葡萄糖溶解是什么

更多相关视频

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

相关概念视频

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

T Cell Activation and Clonal Selection

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

Inhibition of Cdk Activity

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

Synthesis and Regulation of Thyroid Hormones

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...