中线发育在原始链条延伸期间和之后对线粒分裂的差异敏感性
Zhiling Zhao1,2, Rieko Asai1,3, Takashi Mikawa1,2
1Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA.
概括
胚胎中线的发育在胚芽细胞中涉及细胞分裂,特别是在原始链条延伸中. 后原始链条阶段显示出对线粒性停止的一些抵抗力,表明细胞增殖敏感性的不同阶段.
科学领域:
- 发展生物学 发展生物学
- 胚胎发生是胚胎发生.
- 细胞过程 细胞过程
背景情况:
- 中线的建立对于双边胚胎生成至关重要.
- 非氨基体使用平面细胞极性 (PCP) 信号,用于无线分裂的中线形态发生.
- 羊膜细胞在原始链条 (PS) 发育中使用了线粒分裂和PCP.
研究的目的:
- 研究细胞增殖在早期中线发育中的作用.
- 分析细胞分裂要求在前和后原始链条延伸阶段.
- 检查平面细胞极性 (PCP) 信号在后原始链条阶段.
主要方法:
- 胚胎发育中的线索性停止实验.
- 中线结构的形态分析.
- 使用标记基因进行基因表达分析.
- 细胞缩和组织发育的评估.
主要成果:
- 在后原始串行阶段的线索性停止保留了记弦延伸和原始串行回归.
- 胚胎在线粒停滞下显示出横向性损失和对轴间膜细分.
- 细胞,包括中线组织,在线粒停滞期间表现出增大.
结论:
- 胚胎胚胎中早期的中线发育具有对线粒分裂敏感的不同阶段.
- 原始的线条延伸需要线粒分裂和PCP信号.
- 在原始连续扩展后的中线发展显示出对线粒性逮捕的抵抗性,PCP的作用不清楚.
相关概念视频
02:13Determining the Plane of Cell Division
3.3K
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function.
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division...
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division...
3.3K
01:56Gastrulation
56.8K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
56.8K