黑色凝聚剂诱导的毒性和不良临床影响的审查
Yuan Le1, Xilin Li1, Xiaoqing Guo1
1Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR, USA.
概括
黑 cohosh 提取物 (BCE) 是一种受欢迎的补充剂,用于缓解更年期. 然而,研究表明,BCE是无效的,可能导致遗传毒性和严重的肝损伤.
科学领域:
- 草药是一种草药.
- 毒理学 毒理学 毒理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 黑 (Actaea racemosa L) 是一种广泛使用的草药补充剂.
- 它传统上用于缓解因声称具有雌激素效应的更年期症状.
- 最近出现了关于其安全性和有效性的担忧.
研究的目的:
- 审查最新的黑色草提取物 (BCE) 毒理学数据.
- 总结在人类临床试验中报告的不良影响.
- 评估BCE在更年期治疗中的安全性和有效性.
主要方法:
- 对体内和体外实验数据的审查.
- 对人类临床试验不良事件报告的分析.
- 检查化学成分及其潜在影响.
主要成果:
- 最近的研究表明,BCE在更年期治疗中无效.
- 通过一种无遗传作用模式,BCE 证明了基因毒性.
- 人类的不良反应范围从轻微反应到急性肝损伤和死亡.
结论:
- 黑提取物 (BCE) 引发了严重的安全问题.
- 它对更年期症状的有效性值得怀疑.
- 商业产品成分的变化可能会导致不一致的结果和风险.
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