粉症轻链 (AL) 粉症与胃肠道参与:内镜在全身性疾病的诊断价值
Elena Granda Villanueva1, Blanca Mesonero de la Cruz2, José Manuel Campos Martín2
1Aparato Digestivo, Hospital Universitario Central de Asturias, Spain.
Revista espanola de enfermedades digestivas
|June 12, 2025
概括
这项案例研究突出了肠道粉样化症,这是一种罕见的疾病,涉及肠道中的免疫球蛋白轻链沉积物. 早期诊断至关重要,特别是当与多发性骨髓瘤相关时,以有效地管理这种全身性粉样化症.
科学领域:
- 胃肠病学 胃肠病学
- 心脏病学 心脏病学
- 血液学 血液学 血液学
背景情况:
- 肠道粉症涉及免疫球蛋白轻链沉积在肠道,造成损伤.
- 它通常是不特定的,导致诊断不足.
- 最常见的类型是AL氨基粉症,可与多发性骨髓瘤等等离子体细胞失色有关.
研究的目的:
- 要呈现一个多发性骨髓瘤病例与AL氨基粉症,影响心脏和肠道.
- 强调诊断挑战和胃镜的作用.
主要方法:
- 一个76岁的老妇人的病例报告.
- 诊断工具包括心声回声,血清蛋白免疫电泳,带活检的胃镜检查,刚果红色染色,免疫组织化学和骨髓活检.
主要成果:
- 患者出现心力衰竭,后来出现胃肠道出血.
- 胃镜检查显示了十二指肠透;活检证实了AL粉样性粉症.
- 骨髓活检诊断出多发性骨髓瘤与全身性氨基粉症.
结论:
- 用活检检查的胃镜检查对于诊断肠粉症至关重要.
- 这一案例凸显了诊断多发性骨髓瘤与涉及多个器官的AL氨基粉症的复杂性.
相关概念视频
Serum Laboratory Studies, Stool Test, Breath Test
318
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
318
Ultrasound II: Endoscopic Ultrasound and FibroScan
82
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
82
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
96
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
96
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
323
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
323
Endoscopic Procedures III: Video Capsule Endoscopy
86
Capsule endoscopy, or wireless or video capsule endoscopy, is a diagnostic procedure for examining the entire gastrointestinal tract. Patients swallow a capsule about the size of a vitamin tablet. The capsule is equipped with a transmitter, a battery, an LED light source, and a color video camera to capture images throughout the gastrointestinal tract. This procedure is particularly useful for diagnosing conditions such as Crohn's disease, ulcerative colitis, tumors, polyps, ulcers,...
86
Endoscopic Procedures II: Colonoscopy
62
The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
62


