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通过鼻胃管给予解封的达比加特兰:一个病例报告
Akiko Kaneta1, Hideaki Yashima2, Takuya Araki2
1Department of Pharmacy, Gunma University Hospital, Maebashi, Japan.
概括
通过鼻胃管给患有吞困难的患者服用解封的达比加特兰乙酸盐 (DE) 可能是安全有效的. 较低剂量可以达到治疗性达比加特兰度,这表明它是心房动管理的可行替代方案.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
- 内部医学 内部医学
背景情况:
- 达比加特兰乙酸盐 (DE) 是一种用于心房动的直接血栓抑制剂.
- 在患有食障碍的患者或需要肠道养的患者中,出现了管理方面的挑战.
- 关于通过非口服途径服用DE的药理动力学数据有限.
研究的目的:
- 描述通过鼻胃管给患有吞困难的患者注射解封的达比加特兰乙酸盐 (DE).
- 评估通过鼻胃管给药的DE的药理动力学和安全性.
主要方法:
- 一名79岁的男性患者患有心房动和消化不良,通过鼻胃管通过水中悬浮的解囊DE接受治疗.
- 血达比加特兰度和激活的部分血栓形成时间 (aPTT) 被监测.
- 患者接受了减少剂量的DE,持续8天.
主要成果:
- 尽管接受了标准剂量的一半,但患者的血达比加特兰度与完全口服剂量的血度相当.
- 用aPTT表示的凝血状态保持在治疗极限内,没有出血并发症.
- 通过鼻胃管给药可以耐受8天的持续时间.
结论:
- 鼻胃注射解封DE可能是无法服用口服药物的患者的安全有效替代方案.
- 较低剂量可以达到治疗药物水平,可能是由于吸收增加.
- 需要进一步的研究,以充分阐明药理动力学和优化这种注射途径.
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