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Updated: Jun 13, 2025

Production of A SARS-CoV-2 Virus like Particle System to Investigate Viral Life Cycles In Vitro
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SARS-CoV-2 nsp15通过颠覆宿主抗病毒防御来增强病毒的毒性

Allen Caobi1,2, Chia-Ming Su1,2, Christian M Beusch3,4

  • 1Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02118.

Proceedings of the National Academy of Sciences of the United States of America
|June 12, 2025
PubMed
概括

在SARS-CoV-2非结构蛋白15 (nsp15) 通过减少病毒双链RNA (dsRNA) 抑制抗病毒信号. 这种nsp15活性在动物模型中增强病毒毒性和疾病严重程度.

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