雷宁-动脉酶系统在可塑剂心血管影响中的作用:系统性审查
Guilherme Dos Santos Reis1,2, Luiza Mazzali Ferraz1,2, Maria Eduarda Lima da Silva1,2
1Laboratory of Exercise Sciences, Biomedical Institute, Fluminense Federal University, Niteroi, RJ, Brazil.
Cardiovascular toxicology
|June 12, 2025
概括
像双和酸盐这样的可塑化剂会破坏宁-血管素系统 (RAS),导致心血管问题,如高血压和心脏缩. 阻止RAS通路可能会减轻这些有害影响.
科学领域:
- 环境健康 环境健康
- 心血管科学 心血管科学
- 毒理学 毒理学 毒理学
背景情况:
- 消费品中常见的可塑剂包括双和酸盐.
- 接触这些化学物质与不良健康结果,特别是心血管疾病有关.
- 氨酶系统 (RAS) 被认为是这些效应的潜在媒介.
研究的目的:
- 审查塑化剂暴露和RAS调制之间的关系.
- 专注于塑化剂对心血管结果的影响.
- 通过RAS综合目前关于可塑剂诱导心血管影响的证据.
主要方法:
- 在PubMed中进行系统的文献搜索,直到2024年11月,遵循PRISMA指南.
- 关键词包括双,酸盐,RAS成分和心血管术语.
- 选31项研究,其中13篇文章被纳入最终审查.
主要成果:
- 暴露于双A (BPA) 和酸盐会过度激活经典的RAS轴.
- 暴露于BPA会导致高血压,血管扩散和氧化应激.
- 在动物模型中暴露于甲酸盐导致血压升高,血管加厚和心脏缩.
- 这些效应被ACE抑制部分改善,证实了RAS的参与.
结论:
- 雷宁-血管酶系统在可塑化剂引起的心血管损伤中起着关键作用.
- 增塑剂有助于高血压,血管光滑肌肉细胞增殖,心脏缩,纤维化和炎症.
- 未来的研究应该调查反监管RAS轴和新型塑化剂类似物.
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