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Updated: Jun 13, 2025

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
08:49

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

Published on: January 22, 2019

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一个由 thioridazine 衍生的分子通过 IKK 抑制表现出潜在的抗炎活性

Shivmuni Sarup1, Rajat Atre1, Alexander G Obukhov2,3

  • 1Department of Biosciences and Biomedical Engineering (BSBE), Indian Institute of Technology Indore (IITI), Indore, India.

Inflammopharmacology
|June 12, 2025
PubMed
概括

研究人员开发了一种更安全的抗炎药物候选药物,TDZ-D2,通过修改 thioridazine 来降低心脏风险. 这种新化合物在没有显著的hERG通道结合的情况下有效地抑制IKKβ,为炎症性疾病提供了一个有前途的治疗选择.

关键词:
心脏安全性心脏安全性慢性炎症性疾病 慢性炎症性疾病这是一种IKKβ抑制剂.通过NF-κB路径.个性化医疗是个性化的医疗.

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