人类肠道螺旋症呈现为结肠在一个免疫能力强的65岁男性
Sara Zotti1, Lisa Fusaro2, Stefano Di Bella2,3
1Department of Prevention, Trieste University Hospital, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), Trieste, 34100, Italy.
Infection
|June 12, 2025
概括
人类肠道螺旋菌病 (HIS) 可以导致胃肠道症状和结肠在免疫能力强的个体. 这一案例表明,家养猪是潜在的动物源,强调了组织学在诊断中的作用.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 人类肠道螺旋菌病 (HIS) 通常与免疫功能低下的个体或特定的危险因素有关.
- 在免疫能力较强的患者中,HIS的非典型表现需要进一步调查.
研究的目的:
- 在一个免疫能力强的患者中记录一个异常的症状性HIS病例.
- 为了探索HIS.的潜在动物源 (家猪)
- 突出HIS在无法解释的胃肠道病理中的诊断意义.
主要方法:
- 一名65岁的免疫能力强的男性出现了急性腹,腹痛,吐和直肠出血.
- 结肠镜检查显示了结肠;为组织病理学检查采集了活检.
- 用 Warthin-Starry 染色来识别螺旋虫被使用.
主要成果:
- 组织病理学证实了密集的螺旋体殖民,这是HIS的特征,形成了一个"虚假的刷边界".
- 患者经历了10天的口服甲尼达疗程后,症状完全消失.
- 随访结肠镜检查显示粘膜完全愈合,患者仍然没有症状.
结论:
- HIS可能是致病性的,在没有典型风险因素的免疫能力强的人群中引起胃肠道症状和结肠.
- 组织学检查对于诊断异常结肠病变至关重要.
- 动物传播,可能来自像猪这样的家禽,是HIS在既定风险组之外的可信感染途径.
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