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Updated: Jun 13, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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野生型p53DNA结合域和热点突变体的结构动态揭示了致癌性形状变化

Ziqian Zhao1, Gang Wang1, Xiaoxiao Wu1

  • 1Key Laboratory of Exercise and Health Sciences (Ministry of Education), Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, and School of Exercise and Health, Shanghai University of Sport, 399 Changhai Road, Shanghai, 200438, China. qianzhenyu@sus.edu.cn.

Physical chemistry chemical physics : PCCP
|June 12, 2025
PubMed
概括

瘤抑制剂p53 (蛋白53) DNA结合域中的突变破坏了它的功能. 分子动力学揭示了特定突变如何改变p53蛋白质结构,影响癌症的发展,并提供治疗点.

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