加拿大驾驶人口中的毒品流行率
Cynthia Coulter1,2, J Gonzales1, C Coulter1
19-Delta Analytical, LLC, Ontario, CA, USA.
Traffic injury prevention
|June 12, 2025
概括
2024年尤肯州的一项毒品流行调查发现,25%的司机的毒品检测结果呈阳性. 额外的测试显示出更高的阳性率,并确定了非处方药和抗抑郁药物,建议LC-QTOF-MS用于未来的口服液体药物查.
科学领域:
- 法医科学 法医科学 法医科学
- 分析化学 分析化学
- 毒理学 毒理学 毒理学
背景情况:
- 路边药物调查对于理解驾驶障碍至关重要.
- 口服液分析提供了一种方便的方法来检测最近的药物使用情况.
- 以前的研究表明,口服液中药物度与血液中的度相关.
研究的目的:
- 在2024年在尤肯领地进行一项毒品流行路边调查.
- 用LC-QTOF-MS.来选口服液样本的I级和II级化合物.
- 为了比较商业和非商业司机之间的药物使用模式.
主要方法:
- 从志愿驾驶员 (非商业和商业) 收集口服液样本.
- 最初的查使用了对常见药物类别的验证LC-MS/MS方法.
- 进一步分析采用LC-QTOF-MS进行一级和二级化合物的全面查.
主要成果:
- 在额外测试后,两组驾驶员的整体药物阳性率增加到25%.
- 在7.5%的非商业驾驶员和4.5%的商业驾驶员中观察到多重药物使用.
- 非商业 (29 ng/mL) 和商业 (8 ng/mL) 驱动器之间的平均THC度显著不同,不包括异常值.
结论:
- 对于全面的药物流行调查来说,NSC-ADID Tier I和II建议至关重要.
- 建议用于口服液体药物查的液体色谱-飞行质谱时间 (LC-QTOF-MS).
- 该研究强调了驾驶员中使用毒品的普遍性以及先进分析技术的实用性.
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