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Updated: Jun 14, 2025

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用于分离白细胞的微流体系统:从设计到实际应用

Sanjay Mane^1,2, Dhiraj B Puri¹, Vadiraj Hemadri¹

¹Department of Mechanical Engineering, Birla Institute of Technology and Science-Pilani, K K Birla Goa Campus, Zuarinagar, Sancoale, Goa 403726, India.

Critical reviews in analytical chemistry

|June 12, 2025

概括

微流体装置有效地将白细胞 (WBC) 与红细胞 (RBC) 分离,用于诊断. 被动方法提供简单,可扩展的WBC分离,改善点的护理测试的可访问性.

科学领域:

生物医学工程生物医学工程
免疫学免疫学免疫学
微流体学微流体学

背景情况:

准确的诊断需要分离白细胞 (WBC) 和红细胞 (RBC),因为干扰.
微流体技术提供高效,高纯度的白细胞隔离使用最小的血液样本.
目前的局限性包括WBC-to-RBC比率低,隔离与疾病检测的整合有限.

研究的目的:

审查用于WBC隔离的被动微流体技术.
检查分离的白血细胞的原理,应用和生物测试.
确定用于诊断的微流体平台的创新机会.

主要方法:

专注于被动微流体分离方法.
杆因素如RBC度,通道几何形状和流动动力学.
审查现有的商业设备和生物测试.

主要成果:

被动微流体技术证明了WBC分离的简单性和可扩展性.
解决低WBC-to-RBC比率以及将隔离与检测整合起来仍然存在挑战.
现有的技术显示出增强护理点诊断的潜力.

结论:

被动微流体对高纯度的白细胞隔离有希望.
需要进一步的创新,以提高诊断效率和可用性在 point-of-care 设置.
微流体系统可以通过先进的诊断来彻底改变医疗保健的提供.

关键词:

水力动力学是指水力动力学.惯性惯性惯性的微过方式的微过.微流体学在微流体学方面白细胞是白细胞的组成部分.

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