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外部光束辐射治疗的长期结果与或没有同时进行化疗在差异化甲状腺癌的长期结果

Justin Choi¹, Eric Sherman², Edward Christopher Dee³

¹SUNY Downstate Health Sciences University, College of Medicine, Brooklyn, NY, USA.

Thyroid : official journal of the American Thyroid Association

|June 12, 2025

概括

同时化疗 (CRT) 对晚期分化甲状腺癌 (DTC) 仅进行放射治疗 (RT) 没有生存益处. CRT与急性皮肤炎和气管管瘤发育的增加有关,特别是在氨酸激酶抑制剂治疗后.

科学领域:

在瘤学瘤学.
辐射疗法辐射疗法
甲状腺癌研究研究

背景情况:

分化甲状腺癌 (DTC) 可能在初级治疗后复发或持续.
外部光束辐射疗法 (RT) 是对高级DTC的治疗选择,对手术或放射性无反应.
同时化疗 (CRT) 与RT在先进的DTC中的作用尚不清楚.

研究的目的:

评估晚期DTC患者单独RT与CRT的长期结果.
为了比较两个治疗组之间的局部区域控制 (LRC),远程无转移生存率 (DMFS) 和整体生存率 (OS).
评估与单独RT和CRT相关的毒性概况.

主要方法:

从1989年到2023年,对327名患有晚期DTC的患者进行了回顾性队列研究.
患者接受单独RT或CRT,CRT优先用于不完整的切除或不利的组织学.
卡普兰-梅尔法用于分析LRC,DMFS和OS.

主要成果:

在单独的RT和CRT组之间,在4年和10年的LRC,DMFS或OS率中没有观察到显著差异.
接受CRT的患者出现3级+急性皮肤炎的比率显著更高 (29%对10%).
八名患者出现气管食道 (TEF),其中六人接受CRT,随后接受氨酸激酶抑制剂 (TKI) 治疗.

结论:

同时化学辐射 (CRT) 与单独RT相比,对于晚期差异化甲状腺癌 (DTC) 的生存结果没有改善.
CRT与急性皮肤炎的增加和TEF的更高发病率有关,特别是在随后的TKI治疗后.
需要进一步的研究来确定可能受益于CRT的特定患者亚组.

关键词:

化学疗法化疗化疗有差异化的甲状腺癌.头部和部癌症头部和部癌症辐射治疗疗法辐射治疗疗法甲状腺癌是一种癌症.甲状腺手术甲状腺手术

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