代谢异常是完全血清衍生的炎症标志物和糖尿病脚之间的缺失链接吗? 来自大型人口研究的证据
Yang Zhang1, Shumin Zhou2, Xianbin Wang1
1Department of Plastic Surgery, Foresea Life Insurance Guangzhou General Hospital, Guangzhou, Guangdong Province, China.
PloS one
|June 12, 2025
概括
全血清 (CBC) 衍生的炎症标志物预测糖尿病足风险,显示非线性模式. 像肌素和白素这样的代谢因素部分调解这些关联,这表明疾病发展的双重途径.
科学领域:
- 内分泌学和新陈代谢学
- 血液学 血液学 血液学
- 公共卫生 公共卫生
背景情况:
- 糖尿病足是一种严重的糖尿病并发症,由炎症驱动.
- 了解炎症标志物和代谢媒介对于糖尿病足病原发生至关重要.
研究的目的:
- 为了研究全血细胞计 (CBC) 衍生的炎症标志物和糖尿病足之间的关联.
- 评估代谢媒介在这些关系中的作用.
主要方法:
- 对来自NHANES (1999-2004) 的1246名参与者的分析.
- 炎症标志物的计算:单细胞对淋巴细胞的比率 (MLR),中性粒细胞对淋巴细胞的比率 (NLR),中性粒细胞对淋巴细胞的比率 (NMLR) 和全身炎症反应指数 (SIRI).
- 使用加权后勤回归,子组,限制立方线 (RCS) 和调解分析.
主要成果:
- 在CBC衍生的炎症标志物和糖尿病足风险之间发现了显著的正相关性.
- 这些炎症标志物的高四分位数增加了风险.
- 血清肌素和白蛋白部分调解了这些关联,表明非线性关系.
结论:
- 由CBC衍生的炎症标志物是糖尿病足风险的可访问预测因素.
- 非线性模式和代谢因素的部分调解突出显示了双重的炎症代谢途径.
- 常规监测和准代谢异常可以帮助早期风险分层和预防.
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