探索Oroxylum indicum干皮提取物的抗氧化,抗糖和抗炎潜力
Soraya Rodwattanagul1, Pathomwat Wongrattanakamon2,3, Siripat Chaichit2,3
1PhD Degree Program in Pharmacy, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand.
PloS one
|June 12, 2025
概括
奥洛西印第克的提取物显示出强大的抗氧化剂,抗糖化和抗炎作用. 乙酸乙烯分离提取物 (EAFE) 在对抗与氧化应激和炎症相关的退行性疾病方面显示出显著的潜力.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 传统医学的传统医学.
背景情况:
- 退行性疾病通常与氧化应激,糖化和慢性炎症有关.
- 印花 (Oroxylum indicum) 是一种植物,在传统亚洲医学中有着悠久的使用历史.
研究的目的:
- 为了研究Oroxylum indicum提取物的抗氧化,抗糖和抗炎性质.
- 确定导致这些影响的关键生物活性化合物.
主要方法:
- 提取Oroxylum indicum茎皮使用,乙烯酸乙烯和乙醇.
- 高性能液态色谱 (HPLC) 分析以识别化合物.
- 检测总含量 (TPC),总黄含量 (TFC),抗氧化活性和抗糖化活性.
- 在分析中预测抗炎机制.
主要成果:
- 乙酸乙烯分离提取物 (EAFE) 呈现出最高的TPC和TFC.
- EAFE表现出显著的抗氧化和抗糖化活性.
- 在基分析表明通过抑制通类受体4 (TLR4) 的抗炎作用.
结论:
- 在Oroxylum indicum提取物中,TPC和TFC是抗氧化和抗糖化活动的关键决定因素.
- 对于减轻氧化应激,糖化和炎症,EAFE显得有前途.
- 对于Oroxylum indicum在治疗退行性疾病中的传统用途的科学验证.
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