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Updated: Jun 14, 2025

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通过阻断RAS- PI3Kα相互作用,BBO-10203可以抑制瘤生长而不会引起高血糖

Dhirendra K Simanshu1, Rui Xu2, James P Stice2

  • 1NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, USA.

Science (New York, N.Y.)
|June 12, 2025
PubMed
概括

在临床前模型中,BBO-10203是一种针对酸3-酶α (PI3Kα) 的新型口服药物,可显著抑制瘤. 这种PI3Kα抑制剂有效地减少瘤生长而不会引起高血糖症.

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