相关实验视频

Updated: Jun 14, 2025

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes

Published on: April 10, 2015

精细调整硫基连接与的光化学作用 (II) 聚烯基复合物,以获得最佳的PACT应用

Ramranjan Mishra¹, Pritha Chatterjee², Madhu Verma³

¹Indian Institute of Technology Kanpur, Chemistry, Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, 208016, Kanpur, INDIA.

Chemistry (Weinheim an der Bergstrasse, Germany)

|June 12, 2025

概括

鲁丁中的乙烯配体 (((II) - 聚烯基基体显示了光激活化疗 (PACT) 的增强光释放和光细胞毒性. 这些复合体提供了相对于基于硫氧化物的系统相比,更好的选项用于光化前药物.

科学领域:

协调化学协调化学
摄影化学的使用.
药用化学医学化学

背景情况:

乙烯配体在Ru(II) -光激活化疗 (PACT) 的光中有效.
缺乏系统性研究来比较Ru (II) - 聚烯基中的硫结合物 (硫氧化物,硫乙烯) 的光化学行为.

研究的目的:

合成并研究具有硫化物 (DMSO) 和硫乙烯 (DAS) 连接的Ru(II) - 聚烯基的光物理和光化学特性.
为了比较这些复合物的光释放动力学和光细胞毒性,用于PACT应用.

主要方法:

合成两个Ru (II) - 聚烯基复合物:[Ru (ttpy) (phen) DMSO (DMSO) ]PF6) 2和[Ru (ttpy) (phen) DAS (DAS) ]PF6) 2.
使用紫外线和1HNMR光谱的光解研究.
使用HeLa和Caco2细胞系进行体外细胞毒性和光细胞毒性测定.

主要成果:

在MeCN中进行的光溶解研究表明,DMSO (硫氧化物) 的替代速度比DAS (硫乙烯) 慢.
在水中溶解的复合物显示DAS的光释放较容易相比DMSO从Ru (II) -photocages.
[Ru () () (DAS) ] 复合物表现出明显更高的光细胞毒性和光指数,而不是基于DMSO的对应物.

结论:

与基于硫氧化物的系统相比,以铁为基础的Ru (II) - 聚烯基显示出更高的光释放动力学和光细胞毒性.
这些发现突出了基于乙烯的Ru(II) -多基的潜力,作为前药物光和PACT的有希望的候选者.
DAS的容易光释放有助于增强光细胞毒性,支持它们在向癌症治疗中的应用.

关键词:

联结体光替代的作用摄像细胞毒性摄像细胞毒性鲁 (II) 聚二基.摄影化学摄影化学 - 硫键结合了 - 硫.

更多相关视频

[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst

[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst

Published on: May 21, 2019

ARL Spectral Fitting as an Application to Augment Spectral Data via Franck-Condon Lineshape Analysis and Color Analysis

ARL Spectral Fitting as an Application to Augment Spectral Data via Franck-Condon Lineshape Analysis and Color Analysis

Published on: August 19, 2021

相关概念视频

Preparation and Reactions of Sulfides

Preparation and Reactions of Sulfides

Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.

Photochemical Electrocyclic Reactions: Stereochemistry

Photochemical Electrocyclic Reactions: Stereochemistry

The absorption of UV–visible light by conjugated systems causes the promotion of an electron from the ground state to the excited state. Consequently, photochemical electrocyclic reactions proceed via the excited-state HOMO rather than the ground-state HOMO. Since the ground- and excited-state HOMOs have different symmetries, the stereochemical outcome of electrocyclic reactions depends on the mode of activation; i.e., thermal or photochemical.
Selection Rules: Photochemical Activation

Preparation and Reactions of Thiols

Preparation and Reactions of Thiols

Thiols are prepared using the hydrosulfide anion as a nucleophile in a nucleophilic substitution reaction with alkyl halides. For instance, bromobutane reacts with sodium hydrosulfide to give butanethiol.

Electrophilic Aromatic Substitution: Sulfonation of Benzene

Electrophilic Aromatic Substitution: Sulfonation of Benzene

Sulfonation of benzene is a reaction wherein benzene is treated with fuming sulfuric acid at room temperature to produce benzenesulfonic acid. Fuming sulfuric acid is a mixture of sulfur trioxide and concentrated sulfuric acid.

Radical Substitution: Hydrogenolysis of Alkyl Halides with Tributyltin Hydride

Radical Substitution: Hydrogenolysis of Alkyl Halides with Tributyltin Hydride

Radical substitution reactions can be used to remove functional groups from molecules. The hydrogenolysis of alkyl halides is one such reaction, where the weak Sn–H bond in tributyltin hydride reacts with alkyl halides to form alkanes. Here, the reagent Bu3SnH yields tributyltin halide as a byproduct.
The bonds formed in this reaction are stronger than the bonds broken, making it energetically favorable. The reaction follows a radical chain mechanism similar to radical halogenation...

Structure and Nomenclature of Thiols and Sulfides

Structure and Nomenclature of Thiols and Sulfides

Thiols and sulfides are sulfur analogs of alcohols and ethers, respectively, where the sulfur atom takes the place of the oxygen atom. Thus, thiols are generally represented as RSH, where R is an alkyl substituent and —SH is the functional group. On the other hand, in sulfides, the central sulfur atom is bonded to two hydrocarbon groups on either side. Depending upon the type of group, sulfides can be either symmetrical or asymmetrical. Both thiols and sulfides display a bent geometry,...