在雌性大鼠模型中,西丁对循环胺诱导的卵巢功能障碍的改善作用
Abdelmonem Awad Hegazy1, Eman Ramadan Abd El Fattah2, Marwa Mohamed Mahmoud Abdelfattah2
1Human Anatomy and Embryology Department, Faculty of Medicine, Zagazig University, Zagazig City 44519, Egypt; Basic Medical and Clinical Science Department, Faculty of Dentistry, Zarqa University, Zarqa City 13110, Jordan.
Tissue & cell
|June 12, 2025
概括
赫斯佩里丁 (HSP) 可能会防止循环胺 (CP) 诱导的卵巢损伤和不孕症. 这项研究表明,HSP缓解了CP治疗的老鼠的荷尔蒙失衡,氧化应激,并保留了卵巢结构.
科学领域:
- 生殖生物学 生殖生物学
- 药理学 药理学是指药理学的学科.
- 自然产品化学 自然产品化学
背景情况:
- 环胺 (CP) 是一种化疗剂,已知具有卵巢毒性和不孕症副作用.
- 素 (HSP) 是一种黄类化合物,具有抗氧化和抗炎性质,具有潜在的治疗益处.
研究的目的:
- 在大鼠模型中研究素 (HSP) 对循环胺 (CP) 诱导的卵巢损伤和不孕症的保护作用.
- 为了评估HSP对荷尔蒙平衡,氧化应激,基因表达和卵巢组织病理学在CP治疗后的影响.
主要方法:
- 成年雌性白色大鼠被分为四组:对照组,HSP治疗组,CP治疗组和CP+HSP治疗组.
- 分析了荷尔蒙水平 (益生素,雌激素,FSH,LH),氧化应激标志物 (MDA),基因表达 (KISS-1,KISS-1r,GnRH,GnRHr) 和蛋白质表达 (P53,iNOS).
- 卵巢组织检查了他的病理学和免疫组织化学变化.
主要成果:
- CP的使用引发了荷尔蒙失衡,体重和卵巢体重下降,氧化应激增加,基因/蛋白质表达改变.
- 胰腺癌治疗导致卵巢组织发生显著的组织病理损伤.
- 同时服用HSP可减轻CP引起的荷尔蒙干扰,减少氧化应激,使基因表达正常化,并保持卵巢形态.
结论:
- 赫斯佩里丁显示出显著的保护作用,防止循环胺诱导的卵巢损伤和不孕症.
- 在化疗期间,HSP可以作为一种潜在的治疗剂,用于保持女性生育能力.
- 对HSP的机制和临床疗效进行进一步的研究是保证生育保存策略的必要.
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