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Updated: Jun 14, 2025

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增强循环的功能与水友性钻石氨基酸,以改善APC-Asef相互作用的抑制

Shipeng He1, Jie Zhong2, Ziqiang Yu3

  • 1School of Medicine or Institute of Translational Medicine, Shanghai University, Shanghai 200444, China; Shanghai Engineering Research Center of Organ Repair, Shanghai 200444, China.

Bioorganic & medicinal chemistry
|June 12, 2025
PubMed
概括

新型氨基酸增强循环的稳定性和溶解性,改善了蛋白质与蛋白质相互作用 (PPI) 的抑制. 这一策略为转移性结直肠癌提供了一个有前途的治疗方法.

关键词:
在APC-Asef相互作用中.循环类酸是一种循环类酸.水友性钻石氨基酸 友性钻石氨基酸抑制蛋白质与蛋白质的相互作用.

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Various carboxylic acid derivatives (such as acid chlorides, esters, and anhydrides) can be used for the acylation of amines to yield amides. The reaction requires two equivalents of amines. The first amine molecule functions as a nucleophile and attacks the carbonyl carbon to produce a tetrahedral intermediate. This is followed by the loss of the leaving group and restoration of the C=O bond.
Next, the second equivalent of amine serves as a Brønsted base and deprotonates the quaternary...
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