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Ishan C Walpola¹, Adith Mohan¹, Sheryl Foster²

¹Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia; Centre for Healthy Brain Ageing, UNSW Sydney, Sydney, NSW, Australia.

NeuroImage. Clinical

|June 12, 2025

概括

儿童不良体验 (ACE) 与有功能神经障碍 (FND) 的儿童大脑网络连接的改变有关. 这些发现突出了创伤对FND自我处理的影响,并提出了治疗途径.

科学领域:

神经科学是一个神经科学.
儿童心理学儿童心理学
医疗成像医学成像

背景情况:

功能神经障碍 (FND) 的特点是改变自我处理,影响自我代理和自我意识.
大脑网络在自我处理中的改变与FND有关.
了解这些神经支对于FND的诊断和治疗至关重要.

研究的目的:

通过静止状态fMRI研究FND儿童的自我处理大脑网络.
为了检查三个嵌套的自我处理网络的连接性差异:整感受,外感受和心理自我.
探索大脑连接,不良童年经历 (ACE) 和兴奋之间的相关性.

主要方法:

休息状态fMRI用于分析28名患有FND的儿童和31名健康对照的功能连接.
感兴趣的区域 (ROI) 包括胰岛,关节 (TPJ) 和前中间前额叶皮层 (amPFC).
进行了ROI-to-ROI分析和与ACE和心率的相关性分析.

主要成果:

患有FND的儿童在精神自我层上显示了amPFC和thalamus/dlPFC之间功能连接的增加.
功能性发作小组表现出amPFC-TPJ连接性降低.
在FND组中,ACE与胰岛,TPJ和dACC之间的互感层之间的连接正相关.

结论:

儿童不良经历 (ACE) 与儿科FND的自我处理大脑网络的改变有关.
研究结果表明,创伤在FND病理生理学中起着重要作用.
对自我处理的进一步研究可能有利于FND治疗和研究.

关键词:

不良的童年经历 (ACE)转化障碍是一种转化障碍.功能神经系统障碍是一种功能性神经系统障碍.静止状态功能磁共振成像技术自动处理的自动处理.创伤是一个创伤.

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