阿皮克萨班与埃诺克萨巴林用于静脉血栓塞栓症在结肠直肠手术中的预防
Olivia Ziegler1, Alicia C Greene1, Olivia Waldron2
1Department of Surgery, Penn State Hershey Medical Center, Hershey, Pennsylvania.
The Journal of surgical research
|June 12, 2025
概括
在结直肠手术 (CRS) 后,阿皮克萨班显著降低了静脉血栓栓塞 (VTE) 发生率,与结直肠手术 (CRS) 后的埃诺沙巴林相比. 这项研究表明,阿皮克萨班对于接受CRS的患者来说是一种有效的VTE预防方案.
科学领域:
- 医学研究 医学研究
- 临床药理学 临床药理学
- 外科手术的结果
背景情况:
- 术后静脉血栓塞栓症 (VTE) 预防建议用于结直肠癌 (CRC) 患者和高风险个人.
- 对于注射性VTE预防策略的遵守存在挑战.
- 这项研究比较了在结直肠手术 (CRS) 后的VTE预防中使用的apixaban和enoxaparin.
研究的目的:
- 评估阿皮克萨班与埃诺沙巴林在手术后静脉瘤预防中的疗效.
- 为了比较两种预防药物之间的VTE率和出血并发症.
主要方法:
- 从2018年1月到2023年5月的机构数据的回顾性分析.
- 包括1008名接受CRS的患者,其中388人接受了埃诺沙巴林,620人接受了退院后的阿皮克萨班.
- 主要结局:退院后30天内发生VTE;次要结局:出血事件.
主要成果:
- 与埃诺沙巴林 (1.29%) 相比,阿皮克萨班 (0.16%) 的VTE发病率明显较低 (P = 0.023).
- 阿皮克萨班组的老年患者率较高,手术时间较长,侵入性最小的手术和癌症诊断.
- 在阿皮克萨班和埃诺沙巴林组之间,术后出血率没有显著差异.
结论:
- 阿皮克萨班是一种有效的退院后静脉瘤预防药物,用于接受CRS的患者.
- 随着阿皮克萨班的使用,观察到较低的VTE发病率,需要在随机试验中进一步调查.
- 在这种患者群体中,阿皮克萨班为VTE预防提供了一个有前途的替代方案.
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