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通过合金设计和微结构修改增材制造的可生物降解金属来增强骨质和抗菌性能

Yijie Liang¹, Jiabao Dai², Zhenbao Zhang³

¹Postgraduate Training Base Jinzhou Medical University and the Fourth Medical Centre Chinese PLA General Hospital, Beijing, 100048, China; Department of Stomatology, The Fourth Medical Center of PLA General Hospital, Beijing, 100048, China.

|June 12, 2025

概括

这项研究开发了使用激光粉床融合的新型热处理铜植入物. 这些可生物降解的植入物促进骨生长和抗击感染,解决关键的骨科挑战.

科学领域:

生物材料工程生物材料工程
整形外科手术整形外科手术
纳米技术纳米技术

背景情况:

附加制造的金属植入物需要同时进行骨质生成和感染预防.
植入物相关的感染在骨科应用中构成了重大挑战.
可生物降解的基植入物具有潜力,但需要增强功能.

研究的目的:

为可生物降解基植入物开发一种新的战略,将铜合金和热处理结合起来.
在骨科应用中解决骨质生成和感染预防的双重要求.
研究开发的合金的微观结构,机械性能和生物性能.

主要方法:

通过激光粉床融合 (L-PBF) 制造-2%铜 (Zn-2Cu) 植入物.
在350°C进行热处理 (HT) 3小时以诱导沉并修改微观结构.
进行全面的体外和体内测试,以评估骨质生成和抗菌性质.

主要成果:

热处理诱导了CuZn5沉,加速了电腐蚀,并提高了强度 (收益强度为203MPa).
同时释放的Zn2+和Cu2+离子在有利的度下增强了骨质细胞的增殖,分化和骨质生成相关的基因表达.
HT/Zn-2Cu合金表现出强大的抗菌作用,包括生物膜破坏和生长抑制.

结论:

开发的经热处理的Zn-2Cu合金为可生物降解的骨科植入物提供了一个新的范式.
这一策略有效地解决了骨再生和感染预防的同时问题.
这些发现为临床应用中先进的植入物设计铺平了道路.

关键词:

合金设计合金设计抗菌性质抗菌性质抗菌性质激光粉末床融合激光粉末床融合微观结构的修改.骨质发生过程 (osteogenesis)

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