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具有光热反应的库尔库明加载的铜基纳米复合材料用于向药物释放和联合免疫治疗

Anqi Ji¹, Pingjuan Yang², Beng Ma¹

¹School of Materials Science and Engineering, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang 471023, China.

Journal of colloid and interface science

|June 12, 2025

概括

这项研究介绍了一种新的纳米平台,它结合了光热疗法,化疗和PD-L1抑制. 这种方法可以增强抗瘤免疫力,并有效抑制瘤生长,为癌症治疗提供了一个有前途的策略.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症研究癌症研究

背景情况:

化疗,光热疗法 (PTT) 和免疫疗法在癌症治疗方面表现有前途,但在药物释放和调节瘤微环境 (TME) 方面面临挑战.
制定协同策略对于克服治疗耐药性和增强抗瘤免疫反应至关重要.

研究的目的:

开发一个基于Cu9S8的空心纳米平台,用于联合光热化疗和PD-L1抑制.
研究这个纳米平台对癌细胞死亡和抗瘤免疫力的协同效应.

主要方法:

用黄素 (Cur) 和相变材料 (PCM) 装载的空心Cu9S8纳米粒子的制造.
评价光热特性,控制药物释放,以及体外/体内活体抗瘤功效.
免疫细胞死亡 (ICD) 诱导和调节TME的评估,包括PD-L1表达和免疫细胞透.

主要成果:

该纳米平台证明了高效的光热转换,并在NIR照射时触发了黄素的释放.
库尔库协同增强光热剥离,通过ROS生成诱导ICD,并通过抑制EGFR-STAT3通路来降低PD-L1的调节.
在体内研究表明,强大的瘤抑制,并与抗PD-1治疗的结合显著放大了抗瘤免疫力.

结论:

开发的Cu9S8@PCM@Cur纳米平台通过结合PTT,化疗和免疫重编程,提供了多模式的治疗策略.
这种方法有效地抑制瘤生长并增强抗瘤免疫力,为治疗耐药癌症提供了一个有希望的选择.

关键词:

抗PD-1病毒的使用.((9) S ((8)) 的情况.库尔库明是一种黄素.免疫原性细胞死亡光热疗法是一种光热疗法.

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