一项基于真实世界的人口的研究,研究白内障和抗精神病药物之间的关联
Moiz Lakhani1, Angela T H Kwan1, Emaan Chaudry2
1Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Brain and Cognition Discovery Foundation, Toronto, ON, Canada.
概括
第一代抗精神病药物 (FGA) 和第二代抗精神病药物 (SGA) 可能与白内障的发展有关. 在现实世界的安全性分析中, хлорпромазин 和 кветиапин 在白内障的报道几率更高.
科学领域:
- 药物监督和药物安全研究.
- 眼科和药物不良事件分析.
背景情况:
- 抗精神病药物和白内障发展之间的关联仍然不清楚.
- 现实世界的数据对于理解药物安全性概况至关重要.
研究的目的:
- 调查第一代抗精神病药物 (FGA) 和第二代抗精神病药物 (SGA) 与白内障发展之间的潜在关联.
- 在暴露于抗精神病药物的个体中进行白内障不良事件的不成比例分析.
主要方法:
- 一项基于人口的观察性药监测研究,使用美国食品和药物管理局不良事件报告系统 (2003-2024年).
- 使用OpenVigil 2.1分析与FGA和SGA相关的白内障报告,计算报告概率比率 (ROR) 和信息组件 (IC).
主要成果:
- 与其他药物相比, хлорпромазин 和 кветиапин 报告白内障的几率明显更高.
- 对于女性的普罗马和两性和不同年龄组的奎平,观察到白内障报告的增加.
- 在大多数研究的FGA和SGA中,没有发现明显更高的白内障报告几率.
结论:
- 在使用特定的FGA和SGA,特别是普罗马зин和提亚平时,不成比例地报告了白内障的发展.
- 虽然无法证实因果关系,但这些发现强调需要保持警.
- 对于那些处方抗精神病药物的患者,建议定期对眼睛进行监测.
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