在自闭症谱系障碍中肠道微生物群和行为本体:治疗创新的途径
Akanksha Yadav1, Manasi Tadas1, Mayur Kale1
1Division of Neuroscience, Department of Pharmacology, Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur M.S., India 441 002.
Physiology & behavior
|June 12, 2025
概括
肠道微生物组通过肠-大脑轴影响自闭症谱系障碍 (ASD) 的发展和行为. 调节肠道微生物群显示出改善自闭症症状的希望,尽管仍然存在挑战.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 发展心理学 发展心理学
背景情况:
- 自闭症谱系障碍 (ASD) 是一种神经发育状况,其原因复杂.
- 肠-大脑轴,肠道微生物群和中枢神经系统之间的通信网络,越来越多地涉及到ASD.
- 肠道失调症经常在患有自闭症的个体中观察到,并与神经发育的改变有关.
研究的目的:
- 探索肠道微生物群与自闭症相关行为之间的复杂关系.
- 突出肠道微生物群影响ASD神经发育和行为的机制.
- 讨论针对ASD的肠道微生物组的潜在治疗策略.
主要方法:
- 审查关于肠道微生物群和ASD现有的机制研究.
- 对研究肠道衍生代谢物和免疫信号的作用的研究分析.
- 对微生物组调节干预措施的临床证据的审查.
主要成果:
- 肠道微生物群失调与改变的神经发育轨迹和ASD症状严重程度有关.
- 肠道衍生代谢物影响血脑屏障的完整性,神经炎症和神经元发育.
- 怀孕期间母亲的微生物组障碍可能会增加ASD风险.
结论:
- 肠道微生物群在ASD相关行为出现和进展中发挥着重要作用.
- 治疗干预措施,如益生菌,益生菌和饮食改变显示出改善ASD症状的潜力.
- 需要进一步的研究来克服临床翻译方面的挑战,并开发个性化的干预措施.
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