V2b神经元通过多个点作用,在运动过程中产生相位抑制
Mohini Sengupta1,2, Alaina Bertram1, Shuyu Iris Zhu1,3
1Washington University School of Medicine, Department of Neuroscience, St Louis, MO 63110.
概括
脊柱V2b神经元是一个主要的抑制群体,通过抑制运动神经元和其他脊柱细胞来控制运动. 这些神经元在前进游泳和转时活跃,影响运动期间的运动活动.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 脊髓的电路 脊髓的电路
背景情况:
- 脊髓内部神经元对于运动控制至关重要,但它们复杂的电路和远程连接对理解它们的功能构成挑战.
- V2b神经元代表着一个重要的抑制性脊髓人口,在运动时间和行为特异性中起着未知的作用.
- 以前对斑马鱼的研究表明V2b神经元的运动速度很慢,但它们的确切活动模式和目标仍然不清楚.
研究的目的:
- 为了研究V2b神经元在斑马鱼幼虫的运动过程中的精确时间和行为招募.
- 为了绘制V2b神经元超越脊髓内的运动神经元的 postsynaptic 目标.
- 阐明V2b神经元在塑造不同行为的运动神经元活动中的作用.
主要方法:
- 对V2b神经元输出的光遗传映射沿着 rostrocaudal轴.
- 在视觉和电气唤起的运动中,对V2b神经元活动的电生理学记录.
- 在运动和感官刺激期间监测V2b神经元招募的成像.
主要成果:
- V2b神经元广泛抑制运动神经元,V2a,V1和 commissural 内神经元,具有模式的长距离和局部抑制.
- V2b神经元活动专门用于前进的游泳和转,而不是快速逃跑行为.
- V2b抑制与运动突发的上升边缘相应地发生,与V1神经元抑制不同.
结论:
- V2b神经元是轴向运动网络的关键调节者,在运动过程中提供主要的相位抑制.
- 它们的多样化目标和特定的招募模式表明它们在调节节律运动行为方面发挥了作用.
- 这些发现揭示了V2b神经元对运动控制和脊柱电路动力学的明显功能贡献.
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