[由 pembrolizumab 诱导的状硬化症]
Marianne Thérèse Signoret-Bravo1, Fernando De la Barreda-Becerril2, Marcela Saeb-Lima3
1Service de Dermatologie, Hospital General "Doctor Manuel Gea González", Ciudad de México, Mexique.
Annales de pathologie
|June 12, 2025
概括
对癌症的 pembrolizumab 治疗可能会导致免疫相关的不良事件,包括状硬化 (LS). 局部类固醇有效治疗LS而不停止免疫疗法,但恶性瘤监测至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
背景情况:
- 布罗利祖马布是一种PD-1抑制剂,治疗各种癌症,但可以引发与免疫相关的不良事件 (irAEs).
- 免疫检查点抑制剂 (ICI) 与模仿自身免疫性疾病的irAEs有关.
- 状硬化 (LS) 是一种与ICI治疗相关的罕见irrAE,主要在女性患者中观察到.
研究的目的:
- 在接受 pembrolizumab 治疗的肺癌患者中报告状硬化病例 (LS).
- 突出免疫检查点抑制剂 (ICI) 与LS的发展之间的关联.
- 讨论在ICI治疗期间发展LS的患者的管理策略和长期影响.
主要方法:
- 一个44岁的肺癌女性患者的病例报告.
- 关于与pembrolizumab和其他ICI相关的免疫相关不良事件 (irAEs) 的文献综述.
- 对免疫疗法诱导的LS治疗结果的分析.
主要成果:
- 这名患者在接受 pembrolizumab 治疗肺癌期间出现了状硬化 (LS).
- 给予高强度局部皮质类固醇,导致有利的结果.
- 用 pembrolizumab 进行的免疫疗法继续不间断.
结论:
- 状硬化 (LS) 是一种潜在的与免疫相关的不良事件 (irAE),与像 pembrolizumab.com 这样的PD-1 抑制剂相关.
- 局部类固醇治疗是ICI诱导的LS的有效管理策略,允许继续免疫治疗.
- 患有LS的患者需要对潜在的二次恶性瘤,特别是状细胞癌进行警监测.
关键词:
检查点抑制剂检查点抑制剂免疫治疗是一种免疫疗法.控制点的抑制剂 控制点的抑制剂免疫疗法是一种免疫疗法.状状状状状的.这种状状,叫做scléreux.在PD-1中使用PD-1.这就是Pembrolizumab.更多相关视频
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