在接受手术的脊髓转移患者中,预测术后静脉血栓栓塞的新诺米克图:一项回顾性研究
Hui Li1, Xiang Tong1, Xiao Long1
1Department of Orthopedic Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
概括
接受脊髓手术的癌症患者有高风险发生静脉血栓栓塞 (VTE). 确定了9个生物标志物来预测VTE风险,帮助临床决策.
科学领域:
- 在瘤学瘤学.
- 血管外科 血管外科
- 医学诊断 医学诊断 医学诊断
背景情况:
- 静脉血栓塞栓症 (VTE),包括深静脉血栓症 (DVT) 和肺栓塞 (PE),是一种严重的疾病.
- 癌症患者面临着显著增加的静脉瘤风险,比非癌症患者高4-7倍.
- 经过手术的脊髓转移患者是VTE特别易受伤害的群体.
研究的目的:
- 确定在接受手术的脊髓转移癌症患者中VTE的发病率和风险因素.
- 在这个患者群体中开发VTE的预测模型.
主要方法:
- 一项涉及166名经过手术治疗的脊髓转移癌症患者和100名患有脊髓疾病的非癌症患者的比较研究.
- 收集和分析患者特征和临床参数,以确定VTE风险因素.
- 构建和验证基于VTE的nomogram预测模型.
主要成果:
- 在27.20%的癌症患者和2%的非癌症患者中,在术后诊断出VTE (DVT或PE).
- 在癌症患者中发现了九个独立的VTE风险因素,包括手术前和手术后的白蛋白,D-二次体,血小板 (PLT),血红蛋白和纤维素原水平.
- 开发的名图表在预测VTE方面表现出高准确度 (AUC = 0.819),并通过外部验证得到证实.
结论:
- 该研究确定了9个关键生物标志物,用于预测在瘤脊椎手术后癌症患者的静脉动脉突发症.
- 开发的预测模型可以帮助临床医生进行风险评估和临床决策.
- 建议对这些生物标志物的进一步验证用于未来的研究.
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