捐赠淋巴细胞缩和输液的现实实践和挑战:单中心体验
Shuhei Kurosawa1, Kyoko Haraguchi1, Yuho Najima2
1Division of Transfusion and Cell Therapy, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
概括
供体淋巴细胞疏散 (DLA) 数据有限,但这项研究表明细胞计数因供体类型而异. 根据捐赠者和接受者的特征调整DLA至关重要,特别是移植中使用的更多的 haploidentical 捐赠者.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 移植医学 移植医学
背景情况:
- 供体淋巴细胞输液 (DLI) 是一种被公认的移植后免疫调节策略.
- 有限的数据存在于供体淋巴细胞疏散 (DLA) 实践和结果.
研究的目的:
- 分析接受DLI治疗的受体的捐赠淋巴细胞疏散 (DLA) 实践和结果.
- 评估捐赠者类型 (HLA匹配与单一) 对DLA细胞产量和输液参数的影响.
主要方法:
- 对26名获得DLI的受益人的回顾性分析.
- 包括捐赠者:9个与HLA匹配,17个与HAPLO相同.
- 对收获和输注的CD3阳性细胞计数的评估.
主要成果:
- 收获的CD3阳性细胞中位数:6.71 × 10^7细胞/kg,与收获前的数量正相关 (r=0.78).
- 输入的CD3计数在与HLA匹配的DLI和与HAPLOIDENTICAL匹配的DLI之间有显著差异.
- 相对于收获的CD3,输注的CD3的比例在与HLA匹配的DLI (26.3%) 中高于与平分相同的DLI (4.5%) 相比.
结论:
- 这些发现反映了现实世界的DLA实践.
- 强调需要根据捐赠者和接受者的具体情况量身定制DLA程序.
- 强调了优化DLA策略的重要性,并越来越多地使用 haploidentical 捐赠者.
更多相关视频
11:55Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
Published on: March 14, 2011
14.6K
08:05Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
Published on: March 17, 2020
7.8K
相关概念视频
Bone Marrow Sampling and Transplants
316
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
316
Blood Transfusion
530
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
530
Tissue Transplantation
343
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
343
Blood Transfusion and Agglutination
10.8K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.8K
