巨细胞降低NEDD9的调节,以抵消S. Typhimurium介导的FAK-AKT激活和溶酶体抑制

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Updated: Jun 16, 2025

Depletion and Reconstitution of Macrophages in Mice
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Depletion and Reconstitution of Macrophages in Mice

Published on: August 1, 2012

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Julia Fischer1,2,3,4, Lisa Rusyn5, Frederike Krus6

  • 1University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany. julia.fischer2@ukmuenster.de.

Cell death & disease
|June 12, 2025
PubMed
概括

脚手架蛋白质NEDD9阻碍了巨细胞中Salmonella Typhimurium的细菌清除. 消除NEDD9增强了细菌清除和炎症,揭示了NEDD9作为感染的治疗点.

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