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Updated: Jun 16, 2025

Xenopus laevis as a Model to Identify Translation Impairment
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针对性治疗性寡核酸的跨物种转化建模,使用基于生理学的药理动力学

Abdallah Derbalah1, Felix Stader2, Cong Liu2

  • 1Certara Predictive Technologies Division, Certara UK Ltd, Level 2-Acero, 1 Concourse Way, Sheffield, S1 2BJ, UK. Abdallah.Derbalah@Certara.com.

Journal of pharmacokinetics and pharmacodynamics
|June 12, 2025
PubMed
概括

这项研究提出了一种新的全身生理学基础的药物动力学模型,用于预测寡核酸递送. 该模型准确地预测了跨物种的向和非向寡核酸治疗药物的组织吸收,有助于配方开发.

关键词:
在ASO的基础上,ASO是ASO.这就是GalNAcc.有氧核酸类的PBPKK PBPK 的意思是什么意思这就是SiRNA SiRNA.有针对性的药物输送.

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