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Updated: Jun 14, 2025

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
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Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

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针对性单克隆抗体在神经脊髓炎光学谱系障碍中的新兴作用

Angela H Holian1, Brian G Weinshenker2

  • 1Department of Neurology, UVA Specialty Pharmacy, University of Virginia, 1221 Lee Street, 4th Floor PCC, Charlottesville, VA, 22908, USA. arh6j@uvahealth.org.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy
|June 12, 2025
PubMed
概括

新的单克隆抗体 (mAbs) 为AQP4-IgG血清阳性患者提供有效的NMOSD治疗,显著降低攻击频率. 本综述详细介绍了它们的疗效,安全性和与旧疗法相比的使用情况.

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
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Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
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