女性退出高风险MRI查计划后患乳腺癌的女性
Suzanne L van Winkel1, Riccardo Samperna2, Elizabeth A Loehrer2,3
1Medical Imaging Department, Radboudumc: Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. suzanne.vanwinkel@radboudumc.nl.
European radiology
|June 12, 2025
概括
许多高风险女性停止进行乳腺核磁共振扫描,但在此之后仍然患有乳腺癌 (BC). 在停止MRI查后检测到的癌症往往更大,更具侵入性,这表明需要个性化查时间.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 用磁共振成像 (MRI) 进行乳腺癌 (BC) 查,建议对有高终身风险 (≥20%) 的女性进行查.
- 在这个人群中,停止每年进行乳腺MRI查监测是常见的.
- 了解MRI停止后的BC检测率和瘤特征对于优化查指南至关重要.
研究的目的:
- 评估高风险女性的乳腺癌 (BC) 检测,这些女性已停止每年进行乳腺MRI查.
- 为了比较继续和停止MRI查的妇女之间的BC发生率,瘤特征和停止治疗的原因.
主要方法:
- 在2003年至2019年期间,对3308名女性进行了至少一次乳腺核磁共振 (MRI) 的回顾性队列研究.
- 确定了在MRI停止后被诊断出BC的子群体.
- 使用描述性和推断性统计数据比较查指示,BC发病率,瘤特征和停止治疗的原因.
主要成果:
- 2647名妇女停止了MRI查;58名 (2.2%) 在停止后发展了BC.
- 初始MRI的常见指示包括个人/家族BC病史和遗传突变.
- 在MRI停止后检测到的瘤比查期间检测到的瘤更大 (平均差异为7.0毫米),并且比查期间检测到的瘤更具侵入性.
结论:
- 有个人/家族BC病史的妇女经常停止MRI查,通常由医生驱动.
- 许多女性在停止MRI查后被诊断出BC,这挑战了当前的规定.
- 某些高风险女性可能需要超出当前指导方针的扩展,个性化MRI查,这是由于停药后瘤特征恶化.
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