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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
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血清克洛托和糖尿病患者的认知功能之间的相关性分析.

Li Gong1, Qing Ge2

  • 1Department of Neurology and Endocrinology, Chongqing Jiulongpo People's Hospital, No. 23, Yangjiaping Qianjin Road, Jiulongpo District, Chongqing, 400050, China.

Diabetology & metabolic syndrome
|June 12, 2025
PubMed
概括

高血清Klotho水平与糖尿病患者的更好的认知功能相关,特别是在女性中. 这项研究突出了这一群体中克洛托-认知关系中的性别差异.

关键词:
认知功能 认知功能糖尿病 糖尿病 糖尿病尼汉斯 (NHANES) 是一个名人.有限制的立方线.血清克洛托 (Klotho) 是一种血清.

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科学领域:

  • 内分泌学 在内分泌学.
  • 神经科学是一个神经科学.
  • 老年学是指老年学的学科.

背景情况:

  • 克洛托,血糖和认知有联系,但关于克洛托在糖尿病患者认知功能中的作用的数据很少.
  • 了解Klotho对糖尿病认知的影响对于潜在的治疗策略至关重要.

研究的目的:

  • 调查血清Klotho水平与糖尿病患者认知功能之间的关联.
  • 探索这种关系中的潜在的性别差异.

主要方法:

  • 使用了国家健康和营养检查调查 (NHANES) 数据 (2011-2014).
  • 采用了通用线性回归和受限立方线 (RCS) 分析.
  • 进行了性别分层分析,以检查相关性.

主要成果:

  • 血清Klotho水平与糖尿病患者的DSST和整体认知评分正相关.
  • 在女性中观察到Klotho和DSST得分之间的反转U形关系,Ln ((Klotho) 的转折点为6.766 pg/mL.
  • 特别是在女性中发现了显著的相关性,这表明性别特异性影响.

结论:

  • 血清Klotho水平升高与糖尿病患者的认知功能增强有关.
  • 这项研究为糖尿病患者中Klotho认知关联中性别差异提供了新的证据.
  • 这些发现强调了考虑性别的重要性,以了解Klotho在糖尿病认知健康中的作用.