与代谢功能障碍相关的脂肪性肝病 (MASLD) 的复杂性:技术现状审查
Hsiao-Yun Yeh1,2,3, Shang-Wei Lin1, Hsiao-Chin Shen1,4,3
1Department of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Journal of the Chinese Medical Association : JCMA
|June 13, 2025
概括
对代谢功能障碍相关的脂肪性肝病 (MASLD) 和其进展为代谢功能障碍相关的脂肪性肝炎 (MASH) 的新疗法显示出希望. 早期诊断和生活方式的改变对于管理MASLD和预防肝癌等并发症至关重要.
科学领域:
- 肝病学和代谢疾病
- 药理学和治疗学 药理学和治疗学
- 胃肠病学 胃肠病学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题.
- 向代谢功能障碍相关的脂肪肝炎 (MASH),肝硬化和肝细胞癌 (HCC) 的进展带来了重大的临床挑战.
研究的目的:
- 审查MASLD及其并发症的诊断和治疗方面的最新进展.
- 突出新兴的药理学药剂和生活方式干预的重要性.
主要方法:
- 关于MASLD,MASH和相关的HCC的当前文献的综述.
- 分析新的治疗点和治疗策略.
- 强调多学科护理和个性化医疗.
主要成果:
- 几种新型药物类,包括甲状腺激素受体βagonists和各种受体agonists/co-agonists (FXR,PPAR,GLP-1,GIP),为MASLD提供了新的治疗途径.
- 生活方式干预 (饮食,运动) 和多学科合作对于有效管理至关重要.
- 对与MASLD相关的HCC的抗瘤治疗的研究正在探索胰岛素耐药性和肠肝轴等途径.
结论:
- 在了解和治疗MASLD,MASH和HCC方面取得的重大进展为改善患者结果提供了希望.
- 保持警,及时诊断和定期检查对于预防疾病进展和并发症至关重要.
- 结合药物治疗和生活方式修改的个性化方法是有效管理MASLD的关键.
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