维生素D缺乏与夜间一次性单症状尿液尿之间是否存在关系?
1Department of Pediatrics, School of Medicine, Turgut Ozal University, 06560 Malatya, Turkey.
Diagnostics (Basel, Switzerland)
|June 13, 2025
概括
患有初级单症状夜性尿液 (PMNE) 的儿童的维生素D水平显著降低. 维生素D缺乏是儿童尿床的一个关键因素,这表明常规检测和补充可能是有益的.
科学领域:
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 主要单症状夜性尿液 (PMNE) 是一个常见的儿科疾病.
- 维生素D在PMNE中的作用尚未完全理解.
- 维生素D缺乏症在全球普遍存在,特别是在儿童中.
研究的目的:
- 调查维生素D缺乏症与儿童PMNE之间的关联.
- 为了确定PMNE的风险因素.
- 探索维生素D水平与尿尿的频率之间的相关性.
主要方法:
- 追溯病例控制研究涉及307名PMNE患者和254名健康对照 (5-18岁).
- 通过化学发光免疫试验测量血清25(OH) D3水平.
- 统计分析包括曼-惠特尼U,奇方,皮尔森相关性和后勤回归.
主要成果:
- 与对照组相比,PMNE患者的血清25(OH) D3水平显著降低 (p < 0.001).
- 在PMNE组中,维生素D缺乏更为常见.
- 维生素D缺乏 (OR: 3.164) 和家族尿尿病史 (OR: 2.790) 是PMNE的独立风险因素.
- 在维生素D水平和每周尿床频率之间观察到显著的负相关性 (r = -0.377,p < 0.001).
结论:
- 患有PMNE的儿童表现出明显较低的血清25(OH) D3水平.
- 维生素D缺乏是PMNE的一个独立相关因素.
- 建议对PMNE儿童进行常规维生素D水平评估,并调查补充剂对PMNE儿童的益处.
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