用蛋白质,碳水化合物和脂肪为早产婴儿的母乳的个性化目标强化:对神经发育的影响
Niels Rochow1,2,3, Nicolas Gabriel Leier1, Gisela Adrienne Weiss1
1Department of Pediatrics, Paracelsus Medical University, Breslauer Str. 201, 90471 Nürnberg, Germany.
Nutrients
|June 13, 2025
概括
与标准强化 (SF) 相比,母乳的目标强化 (TFO) 改善了早产婴儿的生长和身体组成. 此外,TFO还显示出更好的神经发育潜力,降低发育迟缓的风险.
科学领域:
- 新生儿营养和新生儿发育
- 儿科胃肠病学,肝病学和营养学
- 临床试验研究临床试验研究
背景情况:
- 过早出生的婴儿面临着由于营养缺乏而导致生长限制和发育问题的风险.
- 人母乳的标准强化 (SF) 可能无法满足个体的宏观营养素需求.
- 目标强化 (TFO) 旨在根据测量的母乳含量来个性化营养供应.
研究的目的:
- 评估TFO与SF对早产婴儿生长,身体组成和神经结果的影响.
- 为了比较TFO和SF组之间的宏观营养素摄入量和生长参数.
- 为了评估神经发育结果,使用贝利婴儿和幼儿发育III (BSID-III) 的贝利尺度,在18个月的年龄修正.
主要方法:
- 一个双盲,随机对照试验,涉及早产婴儿 (<30周怀孕).
- 婴儿至少三周接受SF或TFO,TFO组接受基于每周三次母乳分析的模块化调整.
- 69名婴儿的生长,身体组成 (36周的月经后年龄) 和BSID-III分数 (18个月的校正年龄) 被评估.
主要成果:
- 与SF相比,TFO显著增加了蛋白质,脂肪和碳水化合物摄入量,导致体重增加和生长速度更高.
- 在低母乳蛋白水平的婴儿中,TFO导致更高的无脂肪质量.
- 在TFO组的婴儿在认知,语言和运动领域表现出更高的BSID-III分数,在高母乳蛋白质的婴儿中表达语言得到改善;TFO组的婴儿较少,运动BSID-III分数≤70.
结论:
- 在早产婴儿中,TFO有效地增强了生长和身体组成.
- TFO可能有助于改善神经结果,并可能降低发育迟缓的风险.
- 需要进一步的多中心试验来证实TFO对早产婴儿神经发育的益处.
关键词:
身体构成 身体组成碳水化合物 碳水化合物胖胖胖的 胖胖的 胖胖的增长的增长增长的增长增长的增长.人类牛奶是人类的牛奶.牛奶分析 牛奶分析神经发育的神经发育过早出生的婴儿早产.蛋白质蛋白质是蛋白质蛋白质的组成部分.目标防御工事的强化目标.更多相关视频
09:36Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
Published on: July 28, 2022
2.2K
04:16Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings
Published on: February 7, 2025
410
相关概念视频
01:07Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
01:29Drug Dosing: Infants and Children
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
01:17Pharmacokinetics in Pediatric Patients: Drug Distribution
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...