Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

302
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
302
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

275
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
275
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

358
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
358
Antiepileptic Drugs: Calcium Channel Blockers01:17

Antiepileptic Drugs: Calcium Channel Blockers

350
Calcium channel blockers, a class of antiepileptic drugs, regulate the flow of calcium ions within neurons.
Calcium channel blockers exert their antiepileptic effects by targeting T-type calcium channels, which are integral to transmitting nerve signals in the central nervous system. These channels allow the passage of calcium ions, which are vital for neuronal communication. By inhibiting T-type calcium channels, calcium channel blockers effectively reduce the release of neurotransmitters and...
350
Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

151
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
151
Antiepileptic Drugs: Sodium Channel Blockers01:08

Antiepileptic Drugs: Sodium Channel Blockers

464
Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
464

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Expanding clinical variability in FBXW7-related neurodevelopmental disorder: a multicenter case series.

Journal of neurodevelopmental disorders·2026
Same author

Turbocharging synaptic transmission: 12 SNAREpins are required for rapid release of reconstituted synaptic vesicles.

Science advances·2026
Same author

Self-Limited Focal Epilepsies in Childhood: How Many and How to Treat.

Pediatric reports·2026
Same author

WWOX-Related Epileptic Encephalopathy (WOREE Syndrome): Clinical Case Study and Literature Review.

Current issues in molecular biology·2026
Same author

From Growth Trajectory to Functional Decline: Age-Contextualized Nutritional Strategies for Muscle Vulnerability. A Narrative Review.

Nutrients·2026
Same author

Self-limited Neonatal Epilepsy associated with global developmental delay and high-threshold sensory profile: A novel KCNQ3 de novo variant unusually located in the voltage sensor S4 segment of the Kv7.3 channel subunit.

Seizure·2026

相关实验视频

Updated: Jun 16, 2025

Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

3.4K

通过中链甘油三和酸调节AMPA受体,支持儿童的营养干预.

Raffaele Falsaperla1, Vincenzo Sortino2,3, Miguel Angel Soler4

  • 1Department of Medical Science-Pediatrics, University of Ferrara, 44124 Ferrara, Italy.

Nutrients
|June 13, 2025
PubMed
概括

中链甘油三 (MCTs) 通过抑制AMPA受体,显示出治疗儿科耐药性 (DRE) 的前景. 本综述探讨了MCT作为性饮食的补充剂,以及作为改善控制的免费饮食的补充剂.

关键词:
这是一个AMPAPAAMPA.多元化技术 (MCT) 是一种技术.药物耐药性 - 抗药性基因饮食是什么 基因饮食是什么

更多相关视频

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays
10:24

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Published on: May 15, 2018

14.6K
A High-content Assay for Monitoring AMPA Receptor Trafficking
10:34

A High-content Assay for Monitoring AMPA Receptor Trafficking

Published on: January 28, 2019

7.6K

相关实验视频

Last Updated: Jun 16, 2025

Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

3.4K
Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays
10:24

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Published on: May 15, 2018

14.6K
A High-content Assay for Monitoring AMPA Receptor Trafficking
10:34

A High-content Assay for Monitoring AMPA Receptor Trafficking

Published on: January 28, 2019

7.6K

科学领域:

  • 神经科学是一个神经科学.
  • 生物化学 生物化学
  • 儿科神经学 儿科神经学

背景情况:

  • 发育性脑病变 (DEE) 通常会导致严重的认知/运动障碍和不耐药性,对标准药物无反应.
  • 经典的饮食 (KD) 对一些DEE和耐火性有效,但负担很高,坚持度低.
  • 中链甘油三 (MCTs),特别是酸,正在研究直接抑制AMPA受体和减少发作.

研究的目的:

  • 系统地审查MCT附加疗法对经典KD和MCT补充剂在儿童耐药性 (DRE) 免费饮食中的作用.
  • 探索MCT,特别是酸在调节AMPA受体以控制发作的机制.

主要方法:

  • 对2000年1月至2025年1月期间发表的文章进行系统审查.
  • 专注于研究在基因饮食和儿科DRE免费饮食中的MCT.
  • 对MCT对发作影响的临床前和临床证据的分析.

主要成果:

  • MCT,特别是酸,通过AMPA受体的负调节来发挥其抗发作作用.
  • 有证据表明,MCT对儿科DRE的发作有积极的影响.
  • 在基因和不受限制的饮食中,MCTs显示出治疗潜力,作为一种附加疗法.

结论:

  • 通过向AMPA受体,MCT,特别是酸,为儿科DRE提供了一个有希望的治疗途径.
  • 虽然MCT显示出有利的发作结果,但实施和遵守方面的挑战需要进一步研究.
  • 未来的研究应该专注于优化基于MCT的疗法,以对患有DRE的儿童持续控制发作.