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调节肠道微生物群的饮食策略在代谢功能障碍相关的脂肪性肝病 (MASLD) 中

Federica Perazza¹, Laura Leoni², Beatrice Selvatici³

¹Department of Medical and Surgical Sciences, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.

|June 13, 2025

概括

肠道微生物群失衡与代谢功能障碍相关的脂肪性肝病 (MASLD) 以及其严重形式MASH有关. 这篇评论探讨了微生物的作用和治疗策略,例如益生菌对肝脏健康的作用.

科学领域:

肝病学肝病学是一种肝病学.
微生物学微生物学
胃肠病学胃肠病学

背景情况:

代谢功能障碍相关的脂肪性肝病 (MASLD) 和其渐进的形式,代谢功能障碍相关的脂肪性肝炎 (MASH),是全球普遍存在的肝病.
肠道微生物群在MASLD和MASH病原体中的作用正在获得显著的关注.
肠道失生症和透性增加与这些肝病的发展和进展有关.

研究的目的:

审查现有证据,将肠道微生物群的改变与MASLD和MASH联系起来.
探索微生物转移影响肝脏健康和疾病进展的机制.
讨论针对MASLD和MASH的肠道微生物群的潜在治疗干预措施.

主要方法:

关于研究MASLD和MASH的肠道微生物群的综合文献综述.
对肠肝轴及其在代谢性肝脏疾病中的干扰研究的分析.
检查新兴的治疗策略,包括益生菌,益生菌和饮食修改.

主要成果:

肠道微生物群失调和肠道透性增加与MASLD和MASH有关.
微生物失衡有助于胰岛素抵抗和炎症,破坏肠肝轴.
有证据表明,调节肠道微生物群可能是一个有希望的治疗途径.

结论:

肠道微生物群在MASLD和MASH的发展和进展中起着至关重要的作用.
通过诸如益生菌和益生菌等干预措施准肠道微生物群,有可能对这些肝脏疾病进行管理.
进一步的研究对于充分阐明微生物群的作用和优化治疗策略至关重要.

关键词:

马什 (MASH) 是一个非常重要的产品.马斯尔德马斯尔德是什么意思这是NAFLD.纳什·纳什 (Nash Nash) 是一个名为纳什的城市.肝硬化是肝硬化的一种疾病.饮食饮食饮食饮食纤维化纤维化肝脏肝脏肝脏肝脏肝脏肝脏与代谢功能障碍相关的脂肪肝炎.与代谢功能障碍相关的脂肪性肝病.我们的微生物群.非酒精性脂肪性肝病是非酒精性脂肪性肝病.非酒精性型肝炎的疾病.营养营养营养营养门高血压门高血压

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