在急性斯坦福A型剖析中预测术前高乳糖血症的死亡率:一项为期16年的单中心回顾性研究
Nazan Puluca1,2, Christian König1,2, Gunther Wiesner3
1Department of Cardiovascular Surgery, German Heart Center Munich, Technical University of Munich, 80636 Munich, Germany.
Journal of clinical medicine
|June 13, 2025
概括
术前乳酸水平大于3.71mmol/L,强烈预测急性斯坦福A型大动脉解剖手术 (ATAAD) 患者的早期死亡率. 乳糖水平升高表明器官缺血,是30天生存时间最重要的危险因素.
科学领域:
- 心血管外科心血管外科
- 胸部外科手术 胸部外科手术
- 密集护理医学 密集护理医学
背景情况:
- 急性斯坦福A型大动脉剖析 (ATAAD) 是一个关键的手术紧急情况.
- 器官不输血是ATAAD的危及生命的并发症.
- 乳酸盐水平作为厌氧糖解和器官失血的指标.
研究的目的:
- 评估手术前的乳酸盐水平,作为ATAAD手术后患者结果的替代标记.
- 为了确定乳酸酸性化对ATAAD患者死亡率的预测值.
- 分析手术前乳酸盐对短期和长期生存的影响.
主要方法:
- 从2000年至2016年连续306名ATAAD患者的回顾性分析.
- 在手术前获得的血清乳酸测量.
- 用于确定乳酸切点 (3.71 mmol/L) 的最大选定等级统计数据.
主要成果:
- 乳酸盐> 3.71 mmol/L的患者的30天死亡率明显更高 (51.5%与18.7%相比).
- 乳糖水平升高 (> 3.71 mmol/L) 是30天死亡率的最强预测因素 (OR = 7.292).
- 这种关联在总死亡率 (HR = 2.772) 中持续存在,但年龄是30天后长期存活的唯一重要因素.
结论:
- 手术前的乳酸是ATAAD中器官输血缺陷的可访问的代用标记物.
- 术前乳酸水平> 3.71 mmol/L是ATAAD手术后早期死亡的最强预测因素.
- 乳酸盐水平有效地识别了早期不良结果的高风险患者.
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