多发性硬化症患者疫苗接种意愿与实际SARS-CoV-2疫苗接种状态之间的差异:一项纵向研究
Felicita Heidler1,2, Michael Hecker3, Niklas Frahm3
1Department of Neurology, Ecumenic Hainich Hospital gGmbH, 99974 Mühlhausen, Germany.
Journal of clinical medicine
|June 13, 2025
概括
许多患有多发性硬化症 (MS) 的人愿意接种严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 疫苗,但没有接种疫苗. 生活状况和先前治疗史等因素影响了这种疫苗犹.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
- 疫苗学 疫苗学 疫苗学
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染对健康构成重大风险,特别是在患有慢性疾病的人群中.
- 多发性硬化症 (MS) 是一种常见的慢性,免疫媒介的神经疾病,疫苗接种对管理至关重要.
- 了解MS患者的接种意愿和接种率对于公共卫生战略至关重要.
研究的目的:
- 为了比较报告的接受SARS-CoV-2疫苗的意愿与pwMS的实际疫苗接种情况.
- 在 pwMS.中识别导致 SARS-CoV-2 疫苗接种意愿和接种之间的差异的因素.
- 为改善这一弱势群体的疫苗犹和接种提供见解.
主要方法:
- 一项纵向的两中心研究,涉及149名18岁以上的参与者,患有临床隔离综合征或MS.
- 进行了三项调查:基线 (2019年6月至2020年6月),疫苗接种前跟踪 (2020年5月至7月) 和疫苗接种后跟踪 (2021年10月至2022年1月).
- 收集的数据包括社会人口统计,临床和心理信息,以分析疫苗接种情况和影响因素.
主要成果:
- 在149名参与者中,122人 (81.9%) 接种了针对SARS-CoV-2的疫苗,而27人 (18.1%) 仍未接种疫苗.
- 不愿接种疫苗的未接种疫苗的pwMS更不可能与伴侣一起生活,吸烟率更高,服用更多药物,并且已经停止了更多的疾病修饰疗法.
- 这些人也认为流行病政策不合适;没有发现与年龄,性别,抑郁或焦虑有重大关联.
结论:
- 在MS患者中,疫苗接种意愿和实际的SARS-CoV-2疫苗接种状态之间存在着显著的差距.
- 生活状况,吸烟,药物使用,治疗史和对流行病政策的看法等因素与pwMS的疫苗犹有关.
- 这些发现为开发有针对性的干预措施提供了关键的见解,以解决疫苗犹问题,并改善MS群体的SARS-CoV-2疫苗接种率.
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